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Diabetes News

• Dual-wave insulin pump improves postprandial glycemia in type 1 diabetic children
• Topline results from phase Ib and phase IIa clinical trials of KRP-1
• A modified Mediterranean diet reduces ALT levels in obese patients with type 2 diabetes
• Amylin, Lilly Disclose Byetta Deaths

Medical News Today

• Biodel To Report Results Of VIAject™ Pivotal Phase III Clinical Trials At EASD Conference
  Biodel Inc. (Nasdaq: BIOD) announced that it will report results of its two pivotal Phase III clinical trials of VIAject™ in patients with Type 1 and Type 2 diabetes next week at the 44th Annual Meeting of the European Association for the Study of Diabetes in Rome. Two posters summarizing these results, #677 by Flacke et al.
• Physicians Eager To Increase Their First- And Second-Line Prescriptions For Januvia Over The Next Two Years For The Treatment Of Type 2 Diabetes
  Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that Merck's Januvia is currently prescribed most often as a third- or later-line of therapy for the treatment of type 2 diabetes.
• OSI Pharmaceuticals Initiates Clinical Development Program For Anti-Diabetes Candidate, PSN821
  OSI Pharmaceuticals, Inc. (Nasdaq: OSIP) announced that it has initiated a first-in-human clinical study for its G-protein coupled receptor GPR119 agonist, PSN821, which the Company is developing for the treatment of type 2 diabetes. Discovered by OSI's diabetes and obesity research team, PSN821 demonstrated both effective glucose lowering and substantial reductions of body weight in pre-clinical studies.
• Blood 'Fingerprints' For Cancer
  Serum microRNAs (miRNAs) can serve as biomarkers for the detection of diseases including cancer and diabetes, according to research published online this week in Cell Research. The findings pave the way for a revolutionary non-invasive diagnostic tool. miRNAs are a class of naturally occurring small non-coding RNAs that have been linked with cancer development.
• Mechanism Of Cell Death Clarified In Oxidative Stress
  Dr. Marcus Conrad of the Institute of Clinical Molecular Biology and Tumor Genetics at the Helmholtz Zentrum München has decrypted the molecular mechanism through which the death of cells is caused by oxidative stress. This knowledge opens novel perspectives to systematically explore the benefit of targeted therapeutic interventions in the cure of ageing and stress-related degenerative diseases.
• Immune Responses In Disease Monitored
  A recent study (doi:10.1016/j.clim.2008.06.009) published in Clinical Immunology, the official journal of the Clinical Immunology Society (CIS), describes a new method enabling the detection of multiple parameters of single human cells. The report demonstrates the characterization of specific blood cells from an individual with type 1 diabetes, providing information about the role these cells might play in the development of the disease and during therapy.
• Battling Diabetes With Beta Cells
  Affecting eight percent of America's population, diabetes can lead to blindness, kidney failure, strokes and heart disease. Thanks to Tel Aviv University researchers, a new cure - based on advances in cell therapy - may be within reach. Prof. Shimon Efrat from TAU's Sackler Faculty of Medicine, whose research group is among world leaders in beta cell expansion, has developed a way to cultivate cells derived from insulin-producing beta cells from human tissue in the laboratory.
• How Gastric Bypass Rapidly Reverses Diabetes Symptoms
  A report in the September Cell Metabolism, a publication of Cell Press, offers new evidence to explain why those who undergo gastric bypass surgery often show greater control of their diabetes symptoms within days. It also helps to explain why lap-band surgery doesn't offer the same instant gratification. By studying mice that have undergone both procedures, the researchers show that changes in the intestine are the key.
• Are Diabetes And Obesity Linked To Periodontitis?
  The University of Illinois at Chicago has received a two-year federal grant to continue a study on how periodontitis, an inflammatory disease of the tissues surrounding teeth, is linked to type 2 diabetes and obesity. Dr. Keiko Watanabe of the UIC College of Dentistry has found that periodontitis accelerates the onset of insulin resistance in rats fed a high-fat diet.
• Triumphs And Tragedies In Advances In The Management Of Patients With Diabetes Mellitus:
  The need for long term studies to establish the best means of treating Diabetes, was underlined by Prof John Cleland from the University of Hull at the ESC Congress in Munich. Prof Cleland listed the latest treatment available for patients and voiced his concern about the side-effects and efficacy of available anti-diabetic drugs.